Puasa dan Penuaan: Perspektif Fisiologi Molekuler hingga Adaptasi Sistemik

Al Zein, M., Zein, O., Diab, R., Dimachkie, L., Sahebkar, A., Al-Asmakh, M., Kobeissy, F., & Eid, A. H. (2023). Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis. In Biochemical Pharmacology (Vol. 218). Elsevier Inc. https://doi.org/10.1016/j.bcp.2023.115876

Amin, T., & Mercer, J. G. (2016). Hunger and Satiety Mechanisms and Their Potential Exploitation in the Regulation of Food Intake. Current Obesity Reports, 5(1), 106–112. https://doi.org/10.1007/s13679-015-0184-5

Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2018a). Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. In Obesity (Vol. 26, Number 2, pp. 254–268). Blackwell Publishing Inc. https://doi.org/10.1002/oby.22065

Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2018b). Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. In Obesity (Vol. 26, Number 2, pp. 254–268). Blackwell Publishing Inc. https://doi.org/10.1002/oby.22065

Arencibia-Albite, F. (2022). The energy balance theory is an inconsistent paradigm. Journal of Theoretical Biology, 550(August), 111240. https://doi.org/10.1016/j.jtbi.2022.111240

BaHammam, A. S., & Almeneessier, A. S. (2020). Recent Evidence on the Impact of Ramadan Diurnal Intermittent Fasting, Mealtime, and Circadian Rhythm on Cardiometabolic Risk: A Review. In Frontiers in Nutrition (Vol. 7). Frontiers Media S.A. https://doi.org/10.3389/fnut.2020.00028

Bean, A. (2022). The complete guide to sports nutrition (Nine editi). Bloomsburry Sport.

Blasco, M. A., Partridge, L., Serrano, M., Kroemer, G., & Lo, C. (2023a). Hallmarks of aging : An expanding universe. https://doi.org/10.1016/j.cell.2022.11.001

Blasco, M. A., Partridge, L., Serrano, M., Kroemer, G., & Lo, C. (2023b). Hallmarks of aging : An expanding universe. https://doi.org/10.1016/j.cell.2022.11.001

Blundell, J., de Graaf, C., Hulshof, T., Jebb, S., Livingstone, B., Lluch, A., Mela, D., Salah, S., Schuring, E., van der Knaap, H., & Westerterp, M. (2010). Appetite control: methodological aspects of the evaluation of foods. Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 11(3), 251–270. https://doi.org/10.1111/j.1467-789X.2010.00714.x

Booth, D. A. (1972). Postabsorptively induced suppression of appetite and the energostatic control of feeding. Physiology & Behavior, 9(2), 199–202. https://doi.org/https://doi.org/10.1016/0031-9384(72)90235-1

Booth, G., & Strang, J. M. (1936). Changes in Temperature of The Skin Following The Ingestion of Food. Archives of Internal Medicine, 57(3), 533–543. https://doi.org/10.1001/archinte.1936.00170070058005

Bosy-Westphal, A., Jensen, B., Braun, W., Pourhassan, M., Gallagher, D., & Müller, M. J. (2017). Quantification of whole-body and segmental skeletal muscle mass using phase-sensitive 8-electrode medical bioelectrical impedance devices. European Journal of Clinical Nutrition, 71(9), 1061–1067. https://doi.org/10.1038/ejcn.2017.27

Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M. G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., … Longo, V. D. (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism, 22(1), 86–99. https://doi.org/10.1016/j.cmet.2015.05.012

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009). AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature, 458(7241), 1056–1060. https://doi.org/10.1038/nature07813

Carter, S., Clifton, P. M., & Keogh, J. B. (2018). Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial. JAMA Network Open, 1(3), e180756–e180756. https://doi.org/10.1001/jamanetworkopen.2018.0756

Chen, Y., & Zhou, X. (2020). Research progress of mTOR inhibitors. In European Journal of Medicinal Chemistry (Vol. 208). Elsevier Masson s.r.l. https://doi.org/10.1016/j.ejmech.2020.112820

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001). A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 50(8), 1714–1719. https://doi.org/10.2337/diabetes.50.8.1714

de Cabo, R., & Mattson, M. P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. The New England Journal of Medicine, 381(26), 2541–2551. https://doi.org/10.1056/NEJMra1905136

de Castro, J. M., Bellisle, F., Dalix, A. M., & Pearcey, S. M. (2000). Palatability and intake relationships in free-living humans. characterization and independence of influence in North Americans. Physiology & Behavior, 70(3–4), 343–350. https://doi.org/10.1016/s0031-9384(00)00264-x

Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Vincent, M., Schott, W., Wright, K. M., Raj, A., Prateek, G. V, Mullis, M., Hill, W. G., Zeidel, M. L., Peters, L. L., Harding, F., Botstein, D., … Churchill, G. A. (2024). Dietary restriction impacts health and lifespan of genetically diverse mice. Nature, 634(8034), 684–692. https://doi.org/10.1038/s41586-024-08026-3

Dorling, J. L., Martin, C. K., & Redman, L. M. (2020). Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment. In Ageing Research Reviews (Vol. 64). Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2020.101038

Dwaib, H. S., AlZaim, I., Eid, A. H., Obeid, O., & El-Yazbi, A. F. (2021). Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment. In Frontiers in Pharmacology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fphar.2021.626313

Fontana, L., & Partridge, L. (2015). Promoting Health and Longevity through Diet: From Model Organisms to Humans. Cell, 161(1), 106–118. https://doi.org/10.1016/j.cell.2015.02.020

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018a). Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576–590. https://doi.org/10.1038/s41574-018-0059-4

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018b). Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576–590. https://doi.org/10.1038/s41574-018-0059-4

George, F. C. (2006). Fuel metabolism in starvation. Annual Review of Nutrition, 26, 1–22. https://doi.org/10.1146/annurev.nutr.26.061505.111258

Green, C. L., Lamming, D. W., & Fontana, L. (2022a). Molecular mechanisms of dietary restriction promoting health and longevity. In Nature Reviews Molecular Cell Biology (Vol. 23, Number 1, pp. 56–73). Nature Research. https://doi.org/10.1038/s41580-021-00411-4

Green, C. L., Lamming, D. W., & Fontana, L. (2022b). Molecular mechanisms of dietary restriction promoting health and longevity. In Nature Reviews Molecular Cell Biology (Vol. 23, Number 1, pp. 56–73). Nature Research. https://doi.org/10.1038/s41580-021-00411-4

Grima-Reyes, M., Martinez-Turtos, A., Abramovich, I., Gottlieb, E., Chiche, J., & Ricci, J.-E. (2021). Physiological impact of in vivo stable isotope tracing on cancer metabolism. Molecular Metabolism, 53, 101294. https://doi.org/10.1016/j.molmet.2021.101294

Gruber, H.-J., Semeraro, M. D., Renner, W., & Herrmann, M. (2021). Telomeres and Age-Related Diseases. Biomedicines, 9(10). https://doi.org/10.3390/biomedicines9101335

Gurevich-Panigrahi, T., Panigrahi, S., Wiechec, E., & Los, M. (2009). Obesity: pathophysiology and clinical management. Current Medicinal Chemistry, 16(4), 506–521. https://doi.org/10.2174/092986709787315568

Hafekost, K., Lawrence, D., Mitrou, F., O’Sullivan, T. A., & Zubrick, S. R. (2013). Tackling overweight and obesity: Does the public health message match the science? BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-41

Hall, J. E. (2025). Guyton and Hall Textbook of Medical Physiology (15th ed.). Elsevier.

Hall, K. D., Heymsfield, S. B., Kemnitz, J. W., Klein, S., Schoeller, D. A., & Speakman, J. R. (2012). Energy balance and its components: implications for body weight regulation. The American Journal of Clinical Nutrition, 95(4), 989–994. https://doi.org/10.3945/ajcn.112.036350

Harney, D. J., Cielesh, M., Chu, R., Cooke, K. C., James, D. E., Stöckli, J., & Larance, M. (2021). Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms. Cell Reports, 34(9), 108804. https://doi.org/https://doi.org/10.1016/j.celrep.2021.108804

Harris, J. J., Jolivet, R., & Attwell, D. (2012). Synaptic Energy Use and Supply. Neuron, 75(5), 762–777. https://doi.org/10.1016/j.neuron.2012.08.019

Herz, D., Haupt, S., Zimmer, R., Wachsmuth, N., Schierbauer, J., Paul Zimmermann, Priv.-Doz. Dr. Med. Dr. P., Voit, T., Thurm, U., Rilstone, S., & Moser, O. (2023). Efficacy of Fasting in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review. Nutrients, 15. https://doi.org/10.3390/nu15163525

Hill, J. O., Wyatt, H. R., & Peters, J. C. (2012). Energy balance and obesity. Circulation, 126(1), 126–132. https://doi.org/10.1161/CIRCULATIONAHA.111.087213

Hill, J. O., Wyatt, H. R., & Peters, J. C. (2013). The importance of energy balance. European Endocrinology, 9(2), 111–115. https://doi.org/10.17925/ee.2013.09.02.111

Hofer, S. J., Carmona‐Gutierrez, D., Mueller, M. I., & Madeo, F. (2022). The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. EMBO Molecular Medicine, 14(1), 1–20. https://doi.org/10.15252/emmm.202114418

Ibrahim, M., Davies, M. J., Ahmad, E., Annabi, F. A., Eckel, R. H., Ba-Essa, E. M., El Sayed, N. A., Hess Fischl, A., Houeiss, P., Iraqi, H., Khochtali, I., Khunti, K., Masood, S. N., Mimouni-Zerguini, S., Shera, S., Tuomilehto, J., & Umpierrez, G. E. (2020). Recommendations for management of diabetes during Ramadan: update 2020, applying the principles of the ADA/EASD consensus. BMJ Open Diabetes Research & Care, 8(1), e001248. https://doi.org/10.1136/bmjdrc-2020-001248

Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002

James, D. L., Hawley, N. A., Mohr, A. E., Hermer, J., Ofori, E., Yu, F., & Sears, D. D. (2024). Impact of Intermittent Fasting and/or Caloric Restriction on Aging-Related Outcomes in Adults: A Scoping Review of Randomized Controlled Trials. Nutrients, 16(2). https://doi.org/10.3390/nu16020316

Jia, W., & Liu, F. (2021). Obesity: Causes, consequences, treatments, and challenges. In Journal of Molecular Cell Biology (Vol. 13, Number 7, pp. 463–465). Oxford University Press. https://doi.org/10.1093/jmcb/mjab056

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013a). mTOR is a key modulator of ageing and age-related disease. Nature, 493(7432), 338–345. https://doi.org/10.1038/nature11861

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013b). mTOR is a key modulator of ageing and age-related disease. Nature, 493(7432), 338–345. https://doi.org/10.1038/nature11861

Kennedy, G. C. (1953). The role of depot fat in the hypothalamic control of food intake in the rat. Proceedings of the Royal Society of London. Series B, Biological Sciences, 140(901), 578–596. https://doi.org/10.1098/rspb.1953.0009

Kenyon, C. J. (2010). The genetics of ageing. Nature, 464(7288), 504–512. https://doi.org/10.1038/nature08980

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011). AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biology, 13(2), 132–141. https://doi.org/10.1038/ncb2152

Koppold, D. A., Breinlinger, C., Hanslian, E., Kessler, C., Cramer, H., Khokhar, A. R., Peterson, C. M., Tinsley, G., Vernieri, C., Bloomer, R. J., Boschmann, M., Bragazzi, N. L., Brandhorst, S., Gabel, K., Goldhamer, A. C., Grajower, M. M., Harvie, M., Heilbronn, L., Horne, B. D., … Michalsen, A. (2024). International consensus on fasting terminology. Cell Metabolism, 36(8), 1779-1794.e4. https://doi.org/10.1016/j.cmet.2024.06.013

Lafontan, M., & Langin, D. (2009). Lipolysis and lipid mobilization in human adipose tissue. Progress in Lipid Research, 48(5), 275–297. https://doi.org/10.1016/j.plipres.2009.05.001

Laplante, M., & Sabatini, D. M. (2012). mTOR Signaling in Growth Control and Disease. Cell, 149(2), 274–293. https://doi.org/https://doi.org/10.1016/j.cell.2012.03.017

Lee, J., Seroogy, K. B., & Mattson, M. P. (2002). Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. Journal of Neurochemistry, 80(3), 539–547. https://doi.org/10.1046/j.0022-3042.2001.00747.x

Li, K., Wang, C., Wang, Y., Fu, L., & Zhang, N. (2023). Future foods, dietary factors and healthspan. In Journal of Future Foods (Vol. 3, Number 2, pp. 75–98). Beijing Academy of Food Sciences. https://doi.org/10.1016/j.jfutfo.2022.12.001

Liu, G. Y., & Sabatini, D. M. (2020). mTOR at the nexus of nutrition, growth, ageing and disease. Nature Reviews Molecular Cell Biology, 21(4), 183–203. https://doi.org/10.1038/s41580-019-0199-y

Lobstein, T., Powis, J., & Jackson-Leach, R. (2024). World Obesity Atlas 2024.

Longo, V. D., & Mattson, M. P. (2014a). Fasting: Molecular mechanisms and clinical applications. In Cell Metabolism (Vol. 19, Number 2, pp. 181–192). https://doi.org/10.1016/j.cmet.2013.12.008

Longo, V. D., & Mattson, M. P. (2014b). Fasting: Molecular mechanisms and clinical applications. In Cell Metabolism (Vol. 19, Number 2, pp. 181–192). https://doi.org/10.1016/j.cmet.2013.12.008

Longo, V. D., & Panda, S. (2016a). Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. In Cell Metabolism (Vol. 23, Number 6, pp. 1048–1059). Cell Press. https://doi.org/10.1016/j.cmet.2016.06.001

Longo, V. D., & Panda, S. (2016b). Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. In Cell Metabolism (Vol. 23, Number 6, pp. 1048–1059). Cell Press. https://doi.org/10.1016/j.cmet.2016.06.001

López-Lluch, G., & Navas, P. (2016). Calorie restriction as an intervention in ageing. In Journal of Physiology (Vol. 594, Number 8, pp. 2043–2060). Blackwell Publishing Ltd. https://doi.org/10.1113/JP270543

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039

Lowe, D. A., Wu, N., Rohdin-Bibby, L., Moore, A. H., Kelly, N., Liu, Y. E., Philip, E., Vittinghoff, E., Heymsfield, S. B., Olgin, J. E., Shepherd, J. A., & Weiss, E. J. (2020). Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial. JAMA Internal Medicine, 180(11), 1491–1499. https://doi.org/10.1001/jamainternmed.2020.4153

Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015). Essential role for autophagy in life span extension. The Journal of Clinical Investigation, 125(1), 85–93. https://doi.org/10.1172/JCI73946

Majid, A., Osama, M., Noman, M., Nisa, U., & Haider, I. (2023). Effect of Ramadan Fasting on Body Weight and Body Mass Index (BMI) in Public Sector Undergraduate Medical Students of Peshawar. Pakistan Journal of Medical Sciences, 39(3), 662–666. https://doi.org/10.12669/pjms.39.3.7017

Mattson, M. P., Longo, V. D., & Harvie, M. (2017a). Impact of intermittent fasting on health and disease processes. In Ageing Research Reviews (Vol. 39, pp. 46–58). Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2016.10.005

Mattson, M. P., Longo, V. D., & Harvie, M. (2017b). Impact of intermittent fasting on health and disease processes. In Ageing Research Reviews (Vol. 39, pp. 46–58). Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2016.10.005

Mattson, M. P., Longo, V. D., & Harvie, M. (2017c). Impact of intermittent fasting on health and disease processes. Ageing Research Reviews, 39, 46–58. https://doi.org/10.1016/j.arr.2016.10.005

Mayer, J. (1953). Glucostatic mechanism of regulation of food intake. The New England Journal of Medicine, 249(1), 13–16. https://doi.org/10.1056/NEJM195307022490104

Mellinkoff, S. M., Frankland, M., Boyle, D., & Greipel, M. (1956). Relationship Between Serum Amino Acid Concentration and Fluctuations in Appetite. Journal of Applied Physiology, 8(5), 535–538. https://doi.org/10.1152/jappl.1956.8.5.535

Mizushima, N., & Komatsu, M. (2011). Autophagy: renovation of cells and tissues. Cell, 147(4), 728–741. https://doi.org/10.1016/j.cell.2011.10.026

Muhammad, H. F. L. (2017). Obesitas translasional: Aspek klinis dan molekuler dari kejadian obesitasTitle (Edisi Pert). Gadjah Mada University Press.

Neels, J. G., & Olefsky, J. M. (2006). Inflamed fat: what starts the fire? The Journal of Clinical Investigation, 116(1), 33–35. https://doi.org/10.1172/JCI27280

Nurwanti, E., Hadi, H., Chang, J.-S., Chao, J. C.-J., Paramashanti, B. A., Gittelsohn, J., & Bai, C.-H. (2019). Rural–Urban Differences in Dietary Behavior and Obesity: Results of the Riskesdas Study in 10–18-Year-Old Indonesian Children and Adolescents. Nutrients, 11(2813), 1–14.

Ortiz, V. E., & Kwo, J. (2015). Obesity: physiologic changes and implications for preoperative management. BMC Anesthesiology, 15, 97. https://doi.org/10.1186/s12871-015-0079-8

Ozcan, M., Abdellatif, M., Javaheri, A., & Sedej, S. (2024a). Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System. In Canadian Journal of Cardiology (Vol. 40, Number 8, pp. 1445–1457). Elsevier Inc. https://doi.org/10.1016/j.cjca.2024.02.004

Ozcan, M., Abdellatif, M., Javaheri, A., & Sedej, S. (2024b). Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System. In Canadian Journal of Cardiology (Vol. 40, Number 8, pp. 1445–1457). Elsevier Inc. https://doi.org/10.1016/j.cjca.2024.02.004

Panuganti, K. K., Nguyen, M., Kshirsagar, R. K., & Doerr, C. (2025). Obesity (Nursing).

Paoli, A., Tinsley, G. M., Mattson, M. P., De Vivo, I., Dhawan, R., & Moro, T. (2024). Common and divergent molecular mechanisms of fasting and ketogenic diets. In Trends in Endocrinology and Metabolism (Vol. 35, Number 2, pp. 125–141). Elsevier Inc. https://doi.org/10.1016/j.tem.2023.10.001

Papadopoli, D., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirovic, I., & Hulea, L. (2019). mTOR as a central regulator of lifespan and aging. F1000Research, 8. https://doi.org/10.12688/f1000research.17196.1

Parvaresh, A., Razavi, R., Abbasi, B., Yaghoobloo, K., Hassanzadeh, A., Mohammadifard, N., Safavi, S. M., Hadi, A., & Clark, C. C. T. (2019). Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial. Complementary Therapies in Medicine, 47. https://doi.org/10.1016/j.ctim.2019.08.021

Patterson, R. E., & Sears, D. D. (2017a). Metabolic Effects of Intermittent Fasting. https://doi.org/10.1146/annurev-nutr-071816

Patterson, R. E., & Sears, D. D. (2017b). Metabolic Effects of Intermittent Fasting. https://doi.org/10.1146/annurev-nutr-071816

Puchalska, P., & Crawford, P. A. (2017). Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metabolism, 25(2), 262–284. https://doi.org/10.1016/j.cmet.2016.12.022

Purnomo, S. P., Rejeki, P. S., Argarini, R., Halim, S., Rachmayanti, D. A., Permataputri, C. D. A., & Singgih, I. K. (2025a). Regulation of Metabolic Aging Through Adenosine Mono Phosphate-Activated Protein Kinase and Mammalian Target of Rapamycin: A Comparative Study of Intermittent Fasting Variations in Obese Young Women. Nutrients , 17(10). https://doi.org/10.3390/nu17101695

Purnomo, S. P., Rejeki, P. S., Argarini, R., Halim, S., Rachmayanti, D. A., Permataputri, C. D. A., & Singgih, I. K. (2025b). Regulation of Metabolic Aging Through Adenosine Mono Phosphate-Activated Protein Kinase and Mammalian Target of Rapamycin: A Comparative Study of Intermittent Fasting Variations in Obese Young Women. Nutrients , 17(10). https://doi.org/10.3390/nu17101695

Rahma Sari, A., Danendra Risdaryanto, R., Haidar Pradipta, M., Al Qorni, U., Sri Rejeki, P., Argarini, R., Halim, S., & Pranoto, A. (2024). Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women. Federación Española de Asociaciones de Docentes de Educación Física (FEADEF), 53, 1–10.

Rejeki, P. S., Pranoto, A., Widiatmaja, D. M., Utami, D. M., Izzatunnisa, N., Sugiharto, Lesmana, R., & Halim, S. (2024). Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females. Sports, 12(5). https://doi.org/10.3390/sports12050116

Revelo, X. S., Luck, H., Winer, S., & Winer, D. A. (2014). Morphological and inflammatory changes in visceral adipose tissue during obesity. Endocrine Pathology, 25(1), 93–101. https://doi.org/10.1007/s12022-013-9288-1

Ritchie, H., & Roser, M. (2024). Obesity When did obesity increase? How do rates vary across the world? What is the health impact? Our World in Data.

Ruderman, N. B., Xu, X. J., Nelson, L., Cacicedo, J. M., Saha, A. K., Lan, F., & Ido, Y. (2010). AMPK and SIRT1: a long-standing partnership? American Journal of Physiology. Endocrinology and Metabolism, 298(4), E751-60. https://doi.org/10.1152/ajpendo.00745.2009

Rui, L. (2014). Energy metabolism in the liver. Comprehensive Physiology, 4(1), 177–197. https://doi.org/10.1002/cphy.c130024

Salminen, A., & Kaarniranta, K. (2012a). AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Research Reviews, 11(2), 230–241. https://doi.org/10.1016/j.arr.2011.12.005

Salminen, A., & Kaarniranta, K. (2012b). AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Research Reviews, 11(2), 230–241. https://doi.org/10.1016/j.arr.2011.12.005

Santos, A. L., & Sinha, S. (2021). Obesity and aging: Molecular mechanisms and therapeutic approaches. In Ageing Research Reviews (Vol. 67). Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2021.101268

Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010). Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress. In Molecular Cell (Vol. 40, Number 2, pp. 310–322). https://doi.org/10.1016/j.molcel.2010.09.026

Sherwood, L. (2016). Human physiology: From cells to systems (9th editio). Cengage Learning.

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., Newgard, C. B., Farese, R. V. J., de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.), 339(6116), 211–214. https://doi.org/10.1126/science.1227166

Smith, N. K., & Grueter, B. A. (2021). Hunger‐driven adaptive prioritization of behavior. The FEBS Journal, 289(2022), 922–936.

Strilbytska, O., Klishch, S., Storey, K. B., Koliada, A., & Lushchak, O. (2024). Intermittent fasting and longevity: From animal models to implication for humans. In Ageing Research Reviews (Vol. 96). Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2024.102274

Sun, N., Youle, R. J., & Finkel, T. (2016). The Mitochondrial Basis of Aging. Molecular Cell, 61(5), 654–666. https://doi.org/10.1016/j.molcel.2016.01.028

Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018). Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metabolism, 27(6), 1212-1221.e3. https://doi.org/10.1016/j.cmet.2018.04.010

Tang, B. L. (2016). Sirt1 and the Mitochondria. Molecules and Cells, 39(2), 87–95. https://doi.org/10.14348/molcells.2016.2318

UNICEF. (2019). Landscape Analysis of Overweight and Obesity in Indonesia A comprehensive overview of overweight and obesity in Indonesia. https://www.unicef.org/indonesia/reports/landscape-analysis-overweight-and-obesity-indonesia

Van Kleef, E., Van Trijp, J. C. M., Van Den Borne, J. J. G. C., & Zondervan, C. (2012). Successful development of satiety enhancing food products: towards a multidisciplinary agenda of research challenges. Critical Reviews in Food Science and Nutrition, 52(7), 611–628. https://doi.org/10.1080/10408398.2010.504901

Varady, K. A., Bhutani, S., Church, E. C., & Klempel, M. C. (2009). Short-term modified alternate-day fasting: A novel dietary strategy for weight loss and cardioprotection in obese adults. American Journal of Clinical Nutrition, 90(5), 1138–1143. https://doi.org/10.3945/ajcn.2009.28380

Vettor, R., Di Vincenzo, A., Maffei, P., & Rossato, M. (2020). Regulation of energy intake and mechanisms of metabolic adaptation or maladaptation after caloric restriction. Reviews in Endocrine and Metabolic Disorders, 21(3), 399–409. https://doi.org/10.1007/s11154-020-09565-6

Villareal, D. T., Aguirre, L., Gurney, A. B., Waters, D. L., Sinacore, D. R., Colombo, E., Armamento-Villareal, R., & Qualls, C. (2017). Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. The New England Journal of Medicine, 376(20), 1943–1955. https://doi.org/10.1056/NEJMoa1616338

Weichhart, T. (2018). mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Gerontology, 64(2), 127–134. https://doi.org/10.1159/000484629

WHO. (2021). Indonesia : Obesity rates among adults double over past two decades. https://www.who.int/indonesia/news/detail/04-03-2021-indonesia-obesity-rates-among-adults-double-over-past-two-decades

WHO. (2024). Obesity and Overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D’Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., Kang, S., Horvath, T. L., Fahmy, T. M., Crawford, P. A., Biragyn, A., Alnemri, E., & Dixit, V. D. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature Medicine, 21(3), 263–269. https://doi.org/10.1038/nm.3804

Yuliyanasari, N., Rejeki, P. S., Hidayati, H. B., Subsomwong, P., & Miftahussurur, M. (2024). The effect of intermittent fasting on preventing obesity-related early aging from a molecular and cellular perspective. Journal of Medicine and Life, 17(3), 261–272. https://doi.org/10.25122/jml-2023-0370

Yuliyanasari, N., Zamri, E. N., & Miftahussurur, M. (2025). Safety , health improvement , and expression of aging-related genes during 10-day periodic fasting in overweight and obesity. 8(April), 4616–4624. https://doi.org/10.53894/ijirss.v8i3.7573

Yuliyanasari, N., Zamri, E. N., Rejeki, P. S., & Miftahussurur, M. (2024). The Impact of Ten Days of Periodic Fasting on the Modulation of the Longevity Gene in Overweight and Obese Individuals: A Quasi-Experimental Study. Nutrients , 16(18). https://doi.org/10.3390/nu16183112

Zong, Y., Zhang, C. S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J. W., Tian, X., Qi, Q., Wu, Y. Q., Zhang, C., Ye, Z., Lin, S. Y., Piao, H. L., Hardie, D. G., & Lin, S. C. (2019). Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research, 29(6), 460–473. https://doi.org/10.1038/s41422-019-0163-6